Oxycodone: Reactions with other drugs or substances

Last modified: Saturday, 20. June 2009 - 2:35 pm

Oxycodone is a strong prescription analgesic and, as such, it is not advisable to take oxycodone in combination with any other pain medications, including common over-the-counter pain relievers like Tylenol or Advil. If oxycodone taken as prescribed does not relieve the pain adequately, the patient’s doctor can adjust the dose or substitute a stronger drug.
Because oxycodone may intensify the effects of other drugs that cause drowsiness, it should not be taken with antidepressants, antihistamines, anti-anxiety drugs, seizure medications, sedatives, sleeping pills, or muscle relaxants, except under the supervision of a doctor. Patients who may be prescribed oxycodone should tell their doctor if they are taking any of these medications.
Similarly, alcohol should be avoided when taking oxycodone. It, too, increases feelings of drowsiness and can cause dizziness when combined with oxycodone. Avoiding alcohol is especially important when taking pain-relievers containing oxycodone and acetaminophen, as studies have shown that liver damage can occur when even relatively small amounts of alcohol are combined with acetaminophen. A current or past history of alcohol or drug abuse should be carefully considered before oxycodone is prescribed.
When taking an acetaminophen-containing oxycodone drug, it is also important to pay attention to the acetaminophen content in other medications, such as over-the-counter cough or cold remedies. The maximum daily recommended amount of acetaminophen for the average adult should not exceed 4 g per day or 4,000 mg per day.

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