Nitrous Oxide: Reactions with other drugs or substances

Last modified: Saturday, 20. June 2009 - 2:16 pm

When used along with other CNS depressants (such as alcohol) nitrous oxide can stop the user’s breathing, which can be fatal.
Anyone with the condition phenylketonuria (PKU), a metabolic disorder, should be particularly careful about nitrous oxide use. Individuals with PKU require a diet that is high in protein in low in animal fats, which frequently results in a vitamin B12 deficiency. Nitrous oxide can remove even more B12 from these individuals’ bloodstreams, possibly causing mental impairments, as well as severe nerve and brain damage.

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