Nicotine: Reactions with other drugs or substances
Last modified: Saturday, 20. June 2009 - 1:17 pm
Smoking causes the liver to produce more enzymes that break down a variety of drugs, resulting in lower than expected blood levels. It may be necessary to monitor smokers who take other drugs on a long-term basis, and adjust their doses during smoking cessation. These medications include asthma drugs such as theophylline (Slo-Bid, Theo-Dur), blood thinners such as warfarin (Coumadin), antipsychoitc drugs such as Clozapine (Clozaril), migraine drugs such as ergotamine, and some tricyclic antidepressants. Nicotine is also reported to decrease the blood-pressure-lowering effects of drugs such as nifedipine (Procardia), atenolol (Tenormin), and propanolol (Inderal).
Women who use birth control pills should not smoke as they are at increased risk for heart attacks, blood clots, stroke, liver cancer, and gallbladder disease. The risk increases with age (especially over the age of 35) and smoking more than 15 cigarettes per day.