Ketamine: Reactions with other drugs or substances

Last modified: Sunday, 31. May 2009 - 4:47 pm

The consumption of more than one drug over a small window of time and mixing two or more drugs together for a blending of effects is characteristic of club-drug use. As discussed above, ketamine is often mixed with alcohol, GHB, MDMA (ecstasy), rohypnol, and methamphetamine. Some 37% of reported ketamine combination episodes are linked with ecstasy.
Each drug affects the body in a characteristic way. MDMA and methamphetamine for example, are vasoconstrictors, which decrease blood flow to certain parts of the body. Ketamine is a vasodilator, a drug that increases blood flow. Mixing a vasoconstrictor with a vasodilator (combining ecstasy and ketamine, for example) can dramatically increase blood pressure in the user and boost the risk of sudden cardiac arrest or stroke.
Ketamine should never be used with other drugs that decrease breathing; these include alcohol, barbituates, or Valium. Users mixing these drugs risk slowing their breathing and heart rates to dangerously low levels — starving their brains of oxygen and risking permanent brain damage if not death.

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