Benzylpiperazine (Trifluoromethyl-Phenylpiperazine): Composition, Therapeutic use, Treatment, Effects.

Last modified: Thursday, 25. December 2008 - 7:31 am


Official names: Benzylpiperazine (BZP), trifiuoromethylphenylpiperazine (TFMPP), i-benzyl-i, 4-diazacyclo-hexane dihydrochloride

Street names: Legal E, legal X, A2, the substance, piperazine, 2C-T-Z

Drug classifications: Not scheduled, stimulant, hallucinogen


Key terms

ANTHELMINTHIC DRUGS: Drugs that rid the lower intestinal tract of parasitic worms.

DEMENTIA: A type of disease characterized by progressive loss of memory, learning, and thinking ability.

EUPHORIA: An exaggerated feeling of well being.

NEUROTRANSMITTER: Chemical messengers used by nerve cells to communicate with each other.

RECEPTOR: A specialized part of a nerve cell that recognizes neurotransmitters and communicates with other nerve cells.



Chemicals known as piperazines have industrial applications worldwide, and it is legal to purchase bulk quantities of these chemicals on the Internet for this purpose. By changing chemical groups added to the basic piperazine skeletal structure, different chemicals can be formed that vary considerably in their industrial, medical, and mind-altering properties. Piperazine citrate and related compounds destroy intestinal worms, making these chemicals useful in both medical and veterinary preparations. Other medicinal and mind-altering qualities of piperazines are being exploited as possible treatments of depression, psychosis, Alzheimer’s disease, and tumors.

The piperazines influence brain function through their effects on brain chemistry at different receptors, or specialized locations within nerves allowing them to communicate with each other through chemical messengers called neurotransmitters. By stimulating different groups and locations of nerve cells that contain a specific neurotransmitter called serotonin, piperazine derivatives can have varied, profound effects on mood, learning, perceptions, and movement.

Benzylpiperazine (BZP) is one of the more commonly used piperazines on the club scene because it stimulates the brain and central nervous system, to the point of creating hallucinogenic experiences in some users. Although many describe its stimulant effects as noticeably different from those of “speed,” or amphetamines, it is not particularly popular because of its many side effects.

Like BZP, 3-trifluoromethylphenylpiperazine mono-hydrochloride (TFMPP) is a piperazine stimulant. Most users prefer to combine TFMPP with ecstasy (MDMA). Some users report decreased anxiety, increased closeness with others, and feelings of unexplained happiness, but others describe their experiences with these drugs as frightening and extremely unpleasant.

Piperazines are not currently scheduled or classified in the United States, making possession legal. As of August 2001, these chemicals were not controlled under the Controlled Substances Act (CSA). In the United States, some samples of ecstasy pills seized by authorities contain TFMPP. Piperazines sold in bulk over the Internet have made their way to the club and rave scene and are increasingly sold as club drugs to adolescents and young adults, sometimes as ecstasy, but usually as “BZP,” “legal E,” “legal X,” or “A2.” A BZP variant known as 2C-T-Z can be snorted or taken by mouth. Toxic reactions to BZP and TFMPP include their stimulant effects such as dangerously rapid heart rhythms and seizures. As of September 2000, there were two reported deaths from BZP/TFMPP.


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