Endocrine Effects of Marijuana in the Male: Preclinical Studies

The research efforts of many investigators in the recent past have made it abundantly clear that exposure to marijuana has significant effects upon the reproductive system and the effects of cannabinoid treatment are equally significant on both male and female reproductive systems. Among the effects of cannabinoid treatment on the male reproductive system that have been reported arc altered testicular function, in the form of depressed male hormone secretion, and changes in both the quantity and quality of the sperm produced by the seminiferous tubules. There have been changes reported in the weight and in certain of the enzymes associated with the reproductive organs. Much research effort focused on the ability of THC to depress the secretion of the gonadotropins from the pituitary that are responsible for stimulating testosterone production by the Leydig cells of the testis and the action on the hypothalamus to depress gonadotropic releasing hormone (GnRH). Maintenance and regulation of normal reproductive capacity in the male is a complex and highly integrated phenomenon. It requires proper nutritional and hormonal support, not only by the hormones directly involved in reproduction, hut also by the synergistic Read more […]