WHO’s Response to International Drug Control Treaties

I should like to review briefly the activities undertaken by WHO since I last reported to you in Philadelphia June 1979: Scheduling Activities WHO’s recommendations to the Secretary-General of the UN regarding the control status of eight substances were reviewed by the 6th Special Session of the UN Commission on Narcotic Drugs in February 1980 in Vienna. Tilidine and Sufentanil were placed in schedule I of the 1961 Convention while Dextropropoxyphene was placed in schedule II of the same Convention. The Commission agreed with the recommendations of WHO that Phencyclidine continue to be controlled under schedule II of the 1971 Convention as it is needed in veterinary practices. It was also decided that three analogues of PCP (TEP, PHP or PCPY and PCE) be controlled under schedule I and Mecloqualone under schedule II of the 1971 Convention. In September 1980, WHO plans to review the status of a group of 9 substances (anorectics). These are: Phentermine Chlorphentermine Chlortermine Benzphetamine Mazindol Fenfluramine Amfepramone Phenmetrazine Phendimetrazine Phenmetrazine and Amfepramone are already controlled under schedule II and IV respectively of the 1971 Convention. Technical Cooperation Read more […]

Drug-Drug Interactions of Amphetamines

Adrenergic neuron blocking drugs Amphetamines and other stimulatory anorectic agents, apart from fenfluramine, would be expected to impair the hypotensive effects of adrenergic neuron blocking drugs such as guanethidine. Not only do they release noradrenaline from stores in adrenergic neurons and block the reuptake of released noradrenaline into the neuron, but they also impair re-entry of the antihypertensive drugs. Alcohol Alcohol increases blood concentrations of amphetamines. Barbiturates Barbiturates can enhance amfetamine hyperactivity. Benzodiazepines Benzodiazepines can enhance amfetamine hyperactivity. Estradiol Preclinical studies (as well as anecdotal clinical reports) have shown that estrogens, through effects on the central nervous system, can influence behavioral responses to psychoactive drugs. In an unusual crossover study, the subjective and physiological effects of oral D-amfetamine 10 mg were assessed after pretreatment with estradiol. One group of healthy young women used estradiol patches (Estraderm TTS, total dose 0.8 mg), which raised plasma estradiol concentrations to about 750 pg/ml, and a control group used placebo patches. Most of the subjective and physiological effects of amfetamine Read more […]