Effects of Methamphetamine Use

Cerebral Injury and Death from Methamphetamine Use The cerebral damage caused by methamphetamine intoxication can be formidable. Prolonged use is associated with injury to the dopamine system. Essentially, continued methamphetamine use likely leads to axonic degeneration of the dopamine axon terminals in the striatum, frontal cortex, nucleus accumbens, and amygdala. Hypersensitization of neurons occurs, for example, in increasing sensitivity of D-1 receptors. It is important to note that changes in catecholamines alone cannot explain behavior in humans when they are methamphetamine intoxicated. Animal studies across several species demonstrate that high dosages of methamphetamine damage nerve cells. In rats, one high dose is enough to cause damage to neurons; prolonged administration increases the number of neurons that are killed off. In squirrels, a single dose of MDMA (which is structurally similar to methamphetamine and mescaline) in only slight doses significantly damages brain neurons that produce serotonin. Twelve to 18 months after exposure, serotonin-producing nerves grow abnormally or not at all. MDMA selectively damages serotonin neurons in virtually all species. Buffenstein et al. showed through SPECT Read more […]

Drug Info: Therapeutic use. Treatment. Mental and Physiological Effects. Rehab.

Entries are arranged alphabetically and follow a standardized format that allows to easily find information, and also facilitates comparisons of different drugs. Rubrics include: • Official names, Street names: This section lists the alternate names for a substance, including brand names, generic names, and chemical names for drugs, as well as common “street” names for drugs and other substances. • Drug classification: This section lists the type of drug and its classification and schedule by the U.S. Drug Enforcement Administration, if applicable. • Key terms: This is a mini-glossary of terms in the entry that may be unfamiliar to students. • Overview: Historical background is included here, including the drug’s origin, development, and introduction to society. The current impact of the drug is discussed. • Chemical/organic composition: This section includes discussion on the various compositions of the drug, if it is found in pure or altered forms, and whether or not it is often mixed with other substances or drugs. • Ingestion methods: Availability of the drug or substance in different forms, for example, pill or powder, is discussed. • Therapeutic use: This section describes Read more […]

Ephedra: In the news

Ephedra: Composition, Therapeutic use, Usage trends. Treatment and rehabilitation. Ephedra effects. Reactions with other drugs.

Diet Pills: History notes

Diet Pills: Composition, Therapeutic use, Usage trends. Diet Pills effects. Treatment and rehabilitation. Reactions with other drugs.

Diet Pills: Law and order

Diet Pills: Composition, Therapeutic use, Usage trends. Diet Pills effects. Treatment and rehabilitation. Reactions with other drugs.

Diet Pills: Legal consequences

Diet Pills: Composition, Therapeutic use, Usage trends. Diet Pills effects. Treatment and rehabilitation. Reactions with other drugs.

Diet Pills: Personal and social consequences

Diet Pills: Composition, Therapeutic use, Usage trends. Diet Pills effects. Treatment and rehabilitation. Reactions with other drugs.

Diet Pills: Treatment and rehabilitation

Diet Pills: Composition, Therapeutic use, Usage trends. Diet Pills effects. Treatment and rehabilitation. Reactions with other drugs.

Diet Pills: Reactions with other drugs or substances

Diet Pills: Composition, Therapeutic use, Usage trends. Diet Pills effects. Treatment and rehabilitation. Reactions with other drugs.

Diet Pills: Physiological effects

Diet Pills: Composition, Therapeutic use, Usage trends. Diet Pills effects. Treatment and rehabilitation. Reactions with other drugs.