Endocrine Effects of Marijuana in the Male: Preclinical Studies

The research efforts of many investigators in the recent past have made it abundantly clear that exposure to marijuana has significant effects upon the reproductive system and the effects of cannabinoid treatment are equally significant on both male and female reproductive systems. Among the effects of cannabinoid treatment on the male reproductive system that have been reported arc altered testicular function, in the form of depressed male hormone secretion, and changes in both the quantity and quality of the sperm produced by the seminiferous tubules. There have been changes reported in the weight and in certain of the enzymes associated with the reproductive organs. Much research effort focused on the ability of THC to depress the secretion of the gonadotropins from the pituitary that are responsible for stimulating testosterone production by the Leydig cells of the testis and the action on the hypothalamus to depress gonadotropic releasing hormone (GnRH). Maintenance and regulation of normal reproductive capacity in the male is a complex and highly integrated phenomenon. It requires proper nutritional and hormonal support, not only by the hormones directly involved in reproduction, hut also by the synergistic Read more […]

Effect of marijuana the adrenal gland

Cortical Hormones Exposure to stressful situations elicits a prompt secretion of adrenocortical steriods which help the organisms to counteract the stress. The adrenal cortex responds to acute cannabinoid treatment with a prompt rise in corticosterone levels in the plasma. Exposure to a wide range of dosages of THC ranging fran 2 to 50 mg/ kg body weight produced increased corticosterone levels in the plasm of both the rat and the mouse. Dewey et al. () showed that ascorbic acid, which is inversely correlated to adrenal cortical hormne secretion, was depleted fran the adrenal cortex of laboratory rats. Maier and Maitre () demonstrated that. the increased corticosterone in plasma of rats pretreated with THC was accompanied by a decrease in adrenal cortical cholesterol, a precursor to adrenal cortical hormones, and an increase in unesterified fatty acids; however, the rabbit did not respond to THC with a similar increase in wrtisol. Birmingham and Bartova () showed that the response of elevated plasma corticosterone to THC disappeared after 8 days of treatment with a dose of 3 mg/kg body weight. Pertwee () also showed that tolerance developed to the effect of THC on corticosterone levels in muse plasm and did so without Read more […]