Drug-Drug Interactions of Amphetamines

Adrenergic neuron blocking drugs Amphetamines and other stimulatory anorectic agents, apart from fenfluramine, would be expected to impair the hypotensive effects of adrenergic neuron blocking drugs such as guanethidine. Not only do they release noradrenaline from stores in adrenergic neurons and block the reuptake of released noradrenaline into the neuron, but they also impair re-entry of the antihypertensive drugs. Alcohol Alcohol increases blood concentrations of amphetamines. Barbiturates Barbiturates can enhance amfetamine hyperactivity. Benzodiazepines Benzodiazepines can enhance amfetamine hyperactivity. Estradiol Preclinical studies (as well as anecdotal clinical reports) have shown that estrogens, through effects on the central nervous system, can influence behavioral responses to psychoactive drugs. In an unusual crossover study, the subjective and physiological effects of oral D-amfetamine 10 mg were assessed after pretreatment with estradiol. One group of healthy young women used estradiol patches (Estraderm TTS, total dose 0.8 mg), which raised plasma estradiol concentrations to about 750 pg/ml, and a control group used placebo patches. Most of the subjective and physiological effects of amfetamine Read more […]

Brain Impairment And Illicit Drug Abuse

Studies of General and Polydrug Abuse Our more recent understanding of how drug addiction occurs involves the interference of brain reward circuits, resulting in an increase in the desire to use. In particular, it is posited that the amygdala and subregions of the basal forebrain are involved in a mesolimbic dopamine system that activate mesolimbic dopamine function. Repeated use alters dopamine production, resulting in a dysregulation of the brain reward circuitry. The result is a biological addiction to the drug. With such brain involvement and alteration of the brain circuitry, alterations in neuropsychological functioning is likely. A preliminary report of neuropsychological functioning in polydrug abusers by Grant and colleagues noted a study in which 15 polydrug users were administered a comprehensive neuropsychological battery including neuropsychological tests from the Halstead-Reitan Neuropsychological Test Battery, as well as the Wechsler Adult Intelligence Scale and the Minnesota Multiphasic Personality Inventory (MMPI). The 15 polydrug users were compared to a group of 66 psychiatric inpatients. Although both groups demonstrated severe psychopafhology, as measured by the MMPI, the patterns of neuropsychological Read more […]

Inhalants: Physiological effects

Inhalants: Composition, Therapeutic use, Usage trends. Treatment and rehabilitation. Inhalants effects. Reactions with other drugs.

Inhalants: Therapeutic use

Inhalants: Composition, Therapeutic use, Usage trends. Treatment and rehabilitation. Inhalants effects. Reactions with other drugs.

Inhalants: Chemical | Organic composition

Inhalants: Composition, Therapeutic use, Usage trends. Treatment and rehabilitation. Inhalants effects. Reactions with other drugs.

Inhalants: Therapeutic use, Treatment. Inhalants rehab.

Inhalants: Composition, Therapeutic use, Usage trends. Treatment and rehabilitation. Inhalants effects. Reactions with other drugs.

Amyl Nitrite: In the news

Amyl Nitrite: Composition, Therapeutic use, Usage trends. Amyl Nitrite effects. Treatment and rehabilitation. Reactions with other drugs.

Amyl Nitrite: History notes

Amyl Nitrite: Composition, Therapeutic use, Usage trends. Amyl Nitrite effects. Treatment and rehabilitation. Reactions with other drugs.

Amyl Nitrite: Legal consequences

Amyl Nitrite: Composition, Therapeutic use, Usage trends. Amyl Nitrite effects. Treatment and rehabilitation. Reactions with other drugs.

Amyl Nitrite: Personal and social consequences

Amyl Nitrite: Composition, Therapeutic use, Usage trends. Amyl Nitrite effects. Treatment and rehabilitation. Reactions with other drugs.