Salvia Divinorum: Physiological effects

Last modified: Saturday, 20. June 2009 - 3:31 pm

The actions of Salvia divinorum on the physiology of the body have not been studied as of 2002 and are thus unknown. However, other hallucinogenic substances have substantial effects on the autonomic nervous system, the part of the nervous system that governs bodily functions. These effects may include dilation of the pupils, blurred vision, tremors, uncoordination, elevated heart rate, heart palpitations, elevated body temperature, and sweating.
Pharmacological studies of the effects of salvinorin A on mice have shown that the substance acts similarly to mescaline. The animals cease to scamper about as usual. While they appear sedated, the effect is not true sedation, since they are easily stimulated to move by a noise or light touch. The mice also maintain their righting reflex.
In the laboratory, receptor studies have shown no significant activity at more than 40 receptor sites on nerve cells and other tissues, including the monoamine receptors usually involved in producing the effects of hallucinogenic substances. Thus the mechanism of hallucinogenic activity of Salvia divinorum remains unknown.
Harmful side effects
Neither animal nor human toxicity studies of Salvia divinorum have been done. Very little scientific data exist in regard to adverse effects of the substance on the functioning of the human body. However, hallucinogens have been associated with harmful Mental effects.
Long-term health effects
As of 2002, no scientific data exist on the long-term effects of Salvia divinorum on human health. Other hallucinogenic substances have been associated with long-term adverse Mental effects.

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