PCP (Phencyclidine): Reactions with other drugs or substances

Last modified: Saturday, 20. June 2009 - 2:47 pm

PCP is very often used in combination with other drugs, both legal and illegal. Used together, the effects of both drugs are heightened. In particular, PCP has a very sedative effect when used with other sedatives, including alcohol, tranquilizers, anticonvulsants, and nitrous oxide (laughing gas). Because PCP and sedating drugs interact to produce a very sedative effect, it is easy to overdose when taking such combinations. Signs of an overdose include convulsions, coma, seizures, and respiratory arrest.
One study suggests PCP interacts with the active ingredient in marijuana, called THC, to increase the concentrations of PCP in the body. That means that when PCP is taken with marijuana, the effects of the PCP are amplified.

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