Meperidine: Reactions with other drugs or substances
Last modified: Sunday, 31. May 2009 - 5:19 pm
Some who abuse opioids are under the mistaken impression that using alcohol with the drug will enhance its effects. Like meperidine, alcohol is a cental nervous system depressant, so when both are used together, the risk for respiratory depression and death increases. Also, because alcohol impairs judgment, a drunk person is more likely to believe he can handle more of the drug than he truly can, just as many intoxicated people dangerously believe they are much better drivers than they are. Most people who end up in hospital emergency rooms after an opioid overdose were also using alcohol.
Other classes of drugs that should be avoided when using meperidine include benzodiazepines (drugs in the same class as Valium), most antihistamines, and sedatives/hypnotics (sleeping pills). Several types of antidepressants, including tricyclics, selective serotonin reuptake inhibitors (SSRIs, drugs in the same class as Prozac), and especially monoamine oxidase inhibitors (MAOIs), should be used with great caution or not at all in combination with meperidine. In general, any other central nervous system depressant should either be avoided or used under the guidance of a physician when taking meperidine.