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Nitrous Oxide: Reactions with other drugs or substances

When used along with other CNS depressants (such as alcohol) nitrous oxide can stop the user's breathing, which can be fatal.
Anyone with the condition phenylketonuria (PKU), a metabolic disorder, should be particularly careful about nitrous oxide use. Individuals with PKU require a diet that is high in protein in low in animal fats, which frequently results in a vitamin B12 deficiency. Nitrous oxide can remove even more B12 from these individuals' bloodstreams, possibly causing mental impairments, as well as severe nerve and brain damage.

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