Hydromorphone: Reactions with other drugs or substances

Last modified: Sunday, 31. May 2009 - 4:22 pm

Hydromorphone should never be combined with other drugs that depress the central nervous system. Such drugs include sedatives, tranquilizers, alcohol, and anesthetics. In addition, other types of drugs, such as antidepressants, antihistamines, anticonvulsants, and muscle relaxants should not be combined with hydromorphone. All of these combinations can produce excessive drowsiness. Patients should inform their doctor or dentist if they are currently taking any of these medications or have taken them in the last two weeks.
Hydromorphone should not be combined with other pain medications. This includes over-the-counter medications that are commonly used to treat pain, such as Nuprin or Tylenol. If the prescribed dose of hydromorphone does not sufficiently alleviate the pain, then the treating doctor can adjust the dose. The patient should not make adjustments of hydromorphone dose on his or her own or add pain medications to the regimen.
Patients who have received hydromorphone for long periods of time or those with confirmed opioid dependency should not receive the so-called agonist/antagonist analgesics, such as nalbuphine, pen-tazocine, butorphanol, dezocine, and buprenorphine. The use of these drugs in these patients can intensify withdrawal symptoms.

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