Fentanyl: Reactions with other drugs or substances

Last modified: Sunday, 31. May 2009 - 3:33 pm

One of the side effects of fentanyl is drowsiness, so any other medication that causes drowsiness can greatly increase this effect in a user. For this reason, users of fentanyl must not consume alcoholic beverages, because a user can fall asleep quickly and possibly depress the user’s respiratory system even more. Some medications to be avoided include barbiturates, antidepressants, tranquilizers, muscle relaxants, and antihistamines used in some cold medicines.
It is very important that anyone using fentanyl, either pharmaceutical or clandestine, let their health care professional know of their use prior to surgery or when being prescribed other medications. As was discussed earlier, high dosages of fentanyl are deadly. Because it is used in 70% of surgeries today, any additional use of fentanyl during surgery can lead to complications or death.
According to the makers of Duragesic, it is important not to also use slow-release forms of morphine or oxycodone while using the patch. This would include switching between the two forms of medication or using both at the same time. Other medications that can react negatively with fentanyl use include medicines for high blood pressure and seizures.
Patients taking naltrexone (trade name Trexan) must tell their health care professional because the two drugs will cancel any effects that the other has. Some other medications that reduce the effects of fentanyl are buprenorphine, dezocine, nalbuphine, and pentazoncine. These medications also can cause side effects in people who have become physically dependent on fentanyl.

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