Dimethyltryptamine (DMT): Reactions with other drugs or substances

Last modified: Sunday, 31. May 2009 - 1:46 pm

When ingested by mouth, DMT and 5-MeO-DMT have no effect. A naturally occurring stomach enzyme blocks the uptake of DMT into the system. To become active orally, DMT must be combined with monoamine oxydase inhibitors (MAOIs), a highly potent and potentially dangerous medication.
There are significant dangers in using MAOIs. Most MAOIs potentiate the cardiovascular effects of chemicals called tyramines, which are found in a variety of foods. Taken with beans, beer, aged cheese, chicken liver, chocolate, citrus fruits, coffee, cream, figs, pickled herring, wine, or yeast, MAOIs can cause a hypertensive crisis, including a dangerous rise in blood pressure.
Under the influence of DMT, the effects of amphetamines, general anesthetics, sedatives, antihistamines, alcohol, potent analgesics, and anticholinergic and anti-depressant agents are prolonged and intensified.
If used with DMT, certain antipsychotic medications called phenothiazines can be fatal, especially if they are combined with strychnine or belladonna alkaloids.

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