Dextroamphetamine: Reactions with other drugs or substances

Last modified: Saturday, 30. May 2009 - 3:22 pm

Dextroamphetamines interact with a number of drugs and other substances. These include:
• Hypertension drugs. Because amphetamines stimulate the circulatory system and raise blood pressure, they can inhibit the effect of drugs used to lower blood pressure.
• MAOIs. MAO inhibitors, a class of antidepressant drugs, can slow the metabolism of amphetamines. This mix of drugs may result in skyrocketing blood pressure, severe headaches, and potentially fatal neurological damage.
• Tricyclic antidepressants. When taken with dextroamphetamine, the effects of tricyclic antidepressants (such as desipramine) may increase.
Meperidine (Demerol). Amphetamines can increase the analgesic (pain killing) effect of meperidine.
• Ethosuximide (Zerontin). The intestinal absorption of this anti-epileptic drug is effected by dextroamphetamine, which may delay or decrease its effectiveness.
The drug chlorpromazine (Thorazine) blocks the effects amphetamines have on the central nervous system, and is sometimes used to treat cases of amphetamine overdose or intoxication. Additional drugs, foods, and substances that may also counteract dextroamphetamines and make them less effective include antihista-mines, lithium carbonate, haloperidol, and any acidic agent such as fruit juice or ascorbic acid.
Other drugs may increase the effects of dextroamphetamine. For example, bicarbonate and other alkalinizing agents increase the amount of amphetamines absorbed in the digestive system. Thiazides (potassium-depleting diuretics) decrease the amount of amphetamines that leave the body in urine. Also, other central nervous system stimulants, such as cocaine and nicotine, can amplify the stimulating effects of dextroamphetamines.

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