2C-B (Nexus): Physiological effects
Last modified: Saturday, 20. June 2009 - 3:57 pm
There is little information about the toxicity of 2C-B as there are only a limited number of studies done on the drug. However, some conclusions can be draw about its Physiological effects based on studies of drugs that are chemically similar to 2C-B. The drug binds to serotonin receptors in the brain, which is why it has hallucinogenic properties. Serotonin is a neurotransmitter or “messenger” substance that carries information through the peripheral and central nervous systems.
2C-B does not have the same chemical properties as amphetamines, so it does not seem to deplete the serotonin levels in the brain. This means it probably does not damage nerves as amphetamines do. Since 2C-B chemically resembles mescaline, it is likely to increase the heart rate, elevate blood pressure, and raise body temperature. In some people, 2C-B can cause nausea, vomiting, trembling, chills, and nervousness.
The drug is extremely dose-sensitive and even a small increase in dose (a few milligrams) can produce radically different, unpredictable, and potentially violent effects. The most noticeable physical effects are anxiety, muscle clenching, poor coordination, shaking, dilated pupils, and increased blood pressure and heart rate.
2C-B differs in several ways from other commonly abused drugs such as heroin or cocaine. Although their reality-distorting effects may make them attractive and reinforce repeated usage, 2C-B is not physiologically addictive in the same way that opiates or even sedatives are. That means once tolerance is established, 2C-B does not produce long-term physiological craving after its effects have worn off. They also differ in the duration of drug action. Unlike the effects of cocaine, which last for only minutes, and those of heroin, which last for a couple hours, the active effects of 2C-B can continue for up to 12 hours. Only methamphetamine can produce a similar long-lasting effect from a single ingestion.
Harmful side effects
Side effects can vary but the most common is gastrointestinal distress such as nausea, vomiting, cramps, and diarrhea. There have also been reports of allergic reactions, in which the symptoms include red, itchy, watery eyes, runny or stuffy nose, fever, coughing, and sneezing. Harmful Mental effects include agitation, anxiety, difficulty in concentrating, and frightening thoughts and visions long after use has stopped. It has also been known to trigger latent psychological and mental problems.
Some users also report episodes of hallucinogen-persisting perception disorder (HPPD), commonly known as flashbacks. These episodes are spontaneous and repeated, and sometimes involve continuous recurrences of some of the sensory distortions experienced while on the drug. The experiences may include hallucinations, but usually consist of visual disturbances such as seeing false motion at the edges of the field of vision, bright white or color flashes, and halos or trails around or behind moving objects.
Typically, HPPD is persistent and may remain unchanged for years after a person has stopped using the drug. Because HPPD symptoms are easily mistaken for those of other neurological disorders such as stroke or brain tumors, it is often difficult to diagnose. There is no established treatment for HPPD, although some antidepressant drugs may reduce the symptoms. Psychotherapy also is sometimes helpful.
Flashbacks may occur days, months, or years after using the drug, and may include seeing intense colors and other hallucinations. They can be sparked by the use of another drug, stress, fatigue, or physical exercise. The flashbacks can range from mild to intense and include feelings of anxiety. They can last several minutes.
Using 2C-B when a person is sick, depressed, emotionally upset, or angry increases the risk of having a bad experience. Persons with psychiatric disorders, epileptic disorders, and blood circulation problems also run an increased risk of having adverse reactions to the drug. Since 2C-B is a hallucinogenic, it impairs mental functions, greatly increasing the risk of accidents. Persons on 2C-B should not drive, operate machinery, or engage in other potentially dangerous activities.
Bad trips. While using 2C-B, or “tripping,” the person can have strong feelings of anxiety or fear. The hallucinatory effects can be unpleasant and disturbing. They can also be so intense that the person feels they are losing control or going crazy. When negative feelings dominate the experience, it is commonly called a “bad trip.” The reasons for these frightening experiences are not known. They are particularly common among first-time users.
Having a bad trip can cause the user to panic, which can lead to dangerous behavior. Paranoia and feelings of superiority sometimes develop. When a bad experience occurs, the user needs to be reassured or calmed until the immediate effects have passed, which can be eight hours or longer, depending on the dose.
To help a person who is having a bad trip, make sure the user and those around him or her are safe; move and speak to the person in a calm and confident manner; call the individual by name and remind the person who he or she is, if needed; do not leave the person alone. Medical attention and physical restraint are sometimes required if the user becomes violent. The negative feelings usually leave when the drug wears off.
Long-term health effects
There have been no specific studies into the long-term health effects of using 2C-B. However, experience from other drugs such as MDMA, LSD, and mescaline suggest that regular use can leave the user feeling fatigued, disoriented, and anxious. Users may also experience depression, psychotic syndromes, visual illusions, panic attacks, and depersonalization. Women who are pregnant or breastfeeding should not take the drug, as there is the possibility it could damage the fetus or infant.
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